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11 A separate and highly replicated finding is that GLP-1 RAs directly target molecular systems implicated in neurogenesis, neurodifferentiation, neuroplasticity (Neuro-GDP), neuroprotection, and apoptosis ( 12 For example, GLP-1 RAs increase synthesis of cAMP response element-binding protein (CREB), brain-derived neurotrophic factor (BDNF), and glial-derived neurotrophic factor (GDNF), proteins integral to neurotrophic processes

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